The Andrology Blog

The Science & Medicine of Male Reproduction

Hypoosmotic Swelling (HOS) Assay

Hypoosmotic Swelling (HOS) Assay

Sperm with a physically intact and functionally active membrane will respond to changes in osmolality. This property of the sperm is utilized in the HOS assay which has been shown to correlate highly with the ability of sperm to fertilize intact human oocytes in vitro. It also appears to predict in vitro fertilizing capacity of spermatozoa more reliably than the standard sperm parameters.

Dr S


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